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OCR: occurs in and frank Depression, often with associated anxie approximately sixty per cent of patients psychosis may also occur, diabetes Symptoms relating to hypertension and yan mellitus may develop, and patients sho h may be increased susceptibility to infection whi ing as the hidden or suddenly become overwheln ed. body's defence mechanisms are suppres on may be In ACTH-dependent disease, pigmenta sease, present and, with pituitary-dependent asionally headaches and visual-field defects are o sent. All found if a pituitary macroadenoma is p tent, and disease forms may be cyclical or interm nally pituitary-dependent disease may occasi undergo spontaneous remission.